Saito D
Jpn Circ J. 1976 Apr;40(4):363-97. doi: 10.1253/jcj.40.363.
Observations are presented about the effects of four kinds of coronary vasodilators (dipyridamole, oxyfedrine, prenylamine and trimetazidine) on coronary circulation in the heart with coronary sclerosis which has been induced by intravenous injection of allylamine in the dog. Following results are obtained: 1) All of the drugs examined increase coronary blood flow and decrease coronary vascular resistance in the dogs with coronary sclerosis as well as in normal dogs. 2) An amplitude of response of coronary circulation to the coronary vasodilators is significantly less in the dogs with coronary sclerosis than in the normal dogs. 3) The clinical value of coronary vasodilator has been discussed.
本文报道了四种冠状血管扩张剂（双嘧达莫、奥昔非君、普尼拉明和曲美他嗪）对犬冠状动脉硬化心脏冠状循环的影响。通过静脉注射烯丙胺诱导犬冠状动脉硬化。得到以下结果：1）所有受试药物均可增加冠状动脉硬化犬和正常犬的冠状动脉血流量并降低冠状动脉血管阻力。2）冠状动脉硬化犬冠状循环对冠状血管扩张剂的反应幅度明显低于正常犬。3）讨论了冠状血管扩张剂的临床价值。
