Bhadelia R A, Bogdan A R, Wolpert S M, Lev S, Appignani B A, Heilman C B
Department of Radiology, New England Medical Center Hospital, Boston, MA 02111, USA.
Radiology. 1995 Jul;196(1):195-202. doi: 10.1148/radiology.196.1.7784567.
To determine the features of the cardiac cycle-related cerebrospinal fluid (CSF) flow pulsations in with Chiari I malformation before and after decompressive surgery.
Fifteen patients and 23 healthy subjects underwent cine phase-contrast magnetic resonance imaging. Ten patients were also examined after decompressive surgery. Four regions of interest were selected in the upper cervical subarachnoid space and premedullary cistern. Velocity and fraction of the cardiac cycle waveforms were plotted, and amplitude, temporal, and CSF displacement parameters were assessed.
In the Chiari I patients, impaired systolic and unaltered diastolic CSF flow pulsations immediately below the foramen magnum were identified. After surgery, the systolic flow pulsations immediately below the foramen magnum improved. Good correlation with post-surgical improvement was observed.
CSF flow waveform analysis helps demonstrate abnormalities in CSF flow at the foramen magnum and the benefits of decompressive surgery in patients with the Chiari I malformation.
确定减压手术前后Chiari I型畸形患者与心动周期相关的脑脊液（CSF）流动搏动特征。
15例患者和23名健康受试者接受了电影相位对比磁共振成像检查。其中10例患者在减压手术后也接受了检查。在上颈段蛛网膜下腔和延髓前池选择了四个感兴趣区域。绘制心动周期波形的速度和分数，并评估幅度、时间和脑脊液位移参数。
在Chiari I型患者中，发现枕大孔下方的收缩期脑脊液流动搏动受损，舒张期未改变。手术后，枕大孔下方的收缩期流动搏动有所改善。观察到与手术改善有良好的相关性。
脑脊液流动波形分析有助于证明枕大孔处脑脊液流动的异常以及减压手术对Chiari I型畸形患者的益处。
