[格雷戈里奥·马拉尼翁综合大学医院的肝移植项目：对首批100例患者的分析]

[The liver transplant program of the Hospital General Universitario Gregorio Marañón: an analysis of the first 100 patients].

作者信息

Calleja Kempin J, Clemente Ricote G, Pérez Ferreiroa J, Bañares Cañizares R, Polo Melero J R, García Sabrido J L, Valdecantos Montes E, Olmedilla L, Santos L, Pérez Peña J

机构信息

Cirugía General y Aparato Digestivo, Hospital General Universitario Giregorio Marañón.

出版信息

Rev Clin Esp. 1995 Apr;195(4):207-13.

PMID:7784653

Abstract

During a 3-year period between 1990 and 1993, 100 patients received orthotopic liver transplantation at the "Gregorio Marañón" University General Hospital. The mean age of the patients was relatively high (46.9 +/- 10 years), with an important number of cirrhotic patients (91%). The rate of primary liver failure was relatively low (4.5% of transplantations) although 12 cases with more than 55 years were included in the present series. Eleven retransplantations were performed, 8 for early failure of the graft and 3 for chronic failure. Postoperative complications of the graft were vascular in 9 cases, biliary in 17 cases, and acute rejection (cellular) in 70 patients, although only 50 of these patients required treatment with steroid boluses. Infections were diagnosed in 60 cases with 80% of major infections, 6 of them caused by Aspergillus fumigatus that were lethal in all the cases. Postoperative survival was 82%, 72%, 69% and 69% at 1 month, 6 months, 1 year and 2 years respectively.

摘要

在1990年至1993年的3年期间，100例患者在“格雷戈里奥·马拉尼翁”大学综合医院接受了原位肝移植。患者的平均年龄相对较高（46.9±10岁），其中肝硬化患者数量较多（91%）。原发性肝衰竭的发生率相对较低（占移植手术的4.5%），尽管本系列纳入了12例年龄超过55岁的患者。进行了11次再次移植，8次是因为移植物早期失败，3次是因为慢性失败。移植物的术后并发症中，血管并发症9例，胆道并发症17例，70例患者发生急性（细胞性）排斥反应，不过其中只有50例患者需要使用大剂量类固醇进行治疗。60例患者被诊断出感染，其中80%为严重感染，6例由烟曲霉引起，所有这些病例均致死。术后1个月、6个月、1年和2年的生存率分别为82%、72%、69%和69%。