Corbella X, Vadillo M, Cabellos C, Fernandez-Viladrich P, Rufi G
Department of Infectious Diseases, Hospital de Bellvitge, University of Barcelona, Spain.
Scand J Infect Dis. 1995;27(1):93-4. doi: 10.3109/00365549509018984.
Pyrazinamide hepatotoxicity is considered secondary to a direct and dose-related toxic effect. At currently used doses, pyrazinamide provides effective short-term treatment and is free from serious side effects. We report a case of pyrazinamide-induced hepatitis for which the rechallenge data strongly suggest a hypersensitivity mechanism.
吡嗪酰胺肝毒性被认为是直接剂量相关毒性作用的继发效应。在目前使用的剂量下，吡嗪酰胺可提供有效的短期治疗且无严重副作用。我们报告了一例吡嗪酰胺诱发的肝炎病例，再次用药的数据有力地提示了一种超敏反应机制。
