编码哺乳动物核糖体蛋白L19同源物的酿酒酵母RPL19A基因的核苷酸序列及特征分析
Nucleotide sequence and characterization of the Saccharomyces cerevisiae RPL19A gene encoding a homolog of the mammalian ribosomal protein L19.
作者信息
Song J M, Cheung E, Rabinowitz J C
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
出版信息
Yeast. 1995 Apr 15;11(4):383-9. doi: 10.1002/yea.320110411.
A gene designated RPL19A has been identified in the region downstream from the 3'-end of the Saccharomyces cerevisiae MIS1 gene encoding the mitochondrial C1-tetrahydrofolate synthase. The gene codes for the yeast ribosomal protein YL19 which exhibits 57.5% identify with the mammalian ribosomal protein L19. RPL19A is one of two functional copies of the YL19 gene located on chromosome II. The disruption of RPL19A has no effect on the growth of the yeast. The RPL19A gene contains an intron located near the 5'-end. The 5'-flanking region contains one similar and one complete UASrpg upstream activating sequence. RPL19A was also found to be adjacent to the chromosome II AAC3 gene, encoding the mitochondrial ADP/ATP carrier protein.
在酿酒酵母MIS1基因（编码线粒体C1-四氢叶酸合酶）3'端下游区域已鉴定出一个名为RPL19A的基因。该基因编码酵母核糖体蛋白YL19，它与哺乳动物核糖体蛋白L19有57.5%的同源性。RPL19A是位于II号染色体上YL19基因的两个功能拷贝之一。RPL19A的缺失对酵母生长没有影响。RPL19A基因在5'端附近含有一个内含子。5'侧翼区域包含一个相似的和一个完整的上游激活序列UASrpg。还发现RPL19A与II号染色体上编码线粒体ADP/ATP载体蛋白的AAC3基因相邻。
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