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通过⁸⁶Rb⁺外流研究证明GYKI - 12743的钾通道开放活性。

Demonstration of the potassium channel opening activity of GYKI-12743 by 86Rb+ efflux studies.

作者信息

Bakonyi A, Horváth E J

机构信息

Institute for Drug Research, Budapest, Hungary.

出版信息

Acta Physiol Hung. 1994;82(4):295-300.

PMID:7785439
Abstract

It has been demonstrated that the novel antihypertensive compounds GYKI-12743 showed a potassium channel opening effect as studied in rabbit ear arteries with 86Rb+ as K+ marker. GYKI-12743 produced a concentration dependent 86Rb+ efflux in the same concentration range as the well-known K(+)-channel openers, pinacidil and cromakalim.

摘要

已证实，新型抗高血压化合物GYKI - 12743在以86Rb +作为钾标记物的兔耳动脉研究中显示出钾通道开放效应。GYKI - 12743在与著名的钾通道开放剂匹那地尔和克罗卡林相同的浓度范围内产生浓度依赖性的86Rb +外流。

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1
Demonstration of the potassium channel opening activity of GYKI-12743 by 86Rb+ efflux studies.通过⁸⁶Rb⁺外流研究证明GYKI - 12743的钾通道开放活性。
Acta Physiol Hung. 1994;82(4):295-300.
2
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