Seiberth V, Linderkamp O, Vardarli I, Knorz M C, Liesenhoff H
Department of Ophthalmology, Klinikum Mannheim, Faculty for Clinical Medicine, University of Heidelberg, Germany.
Am J Ophthalmol. 1995 Jun;119(6):748-51. doi: 10.1016/s0002-9394(14)72780-1.
To determine possible side effects of diode laser photocoagulation for threshold retinopathy of prematurity in eyes with tunica vasculosa lentis.
In a prospective clinical study, threshold retinopathy of prematurity was treated in 14 eyes of seven consecutive preterm infants with tunica vasculosa lentis (birth weight, 480 to 980 g; mean +/- S.D., 777 +/- 175 g; gestational age, 24 to 27 weeks; mean +/- S.D., 25.7 +/- 0.9 weeks) by using the diode laser indirect ophthalmoscope. Main outcome measure was the incidence of adverse treatment effects. Follow-up included anterior segment examination with a hand-held slit lamp and ranged from seven to 17 months (12.6 +/- 3.5 months).
The tunica vasculosa lentis did not interfere with photocoagulation in any of the 14 eyes. Laser power ranged from 200 to 400 mW (260 +/- 52 mW). Duration of a single spot was 200 msec. Number of burns ranged from 1,060 to 2,132 (1,556 +/- 315). Retinopathy of prematurity regressed in all eyes, and the outcome was a flat, attached retina. A small amount of postoperative anterior chamber bleeding was noticed in one eye (7% of the eyes, 14% of the patients). There were neither lenticular opacities nor cataract formation.
Diode laser photocoagulation with the laser indirect ophthalmoscope can be used safely in eyes with tunica vasculosa lentis. At the laser energy levels used in our study, no transient lens opacities or cataract formation occurred. However, the results of this study are limited by a relatively small number of patients and a relatively short follow-up.
确定二极管激光光凝治疗伴有晶状体血管膜的阈值早产儿视网膜病变时可能出现的副作用。
在一项前瞻性临床研究中，连续7例伴有晶状体血管膜的早产儿（出生体重480至980克；平均±标准差，777±175克；胎龄24至27周；平均±标准差，25.7±0.9周）的14只眼睛接受了阈值早产儿视网膜病变治疗，使用二极管激光间接检眼镜。主要观察指标为不良治疗效果的发生率。随访包括使用手持裂隙灯进行眼前节检查，随访时间为7至17个月（12.6±3.5个月）。
14只眼中晶状体血管膜均未干扰光凝治疗。激光功率范围为200至400毫瓦（260±52毫瓦）。单个光斑持续时间为200毫秒。烧灼点数范围为1060至2132（1556±315）。所有眼睛的早产儿视网膜病变均消退，结果为视网膜扁平且附着。一只眼睛出现少量术后前房出血（占眼睛的7%，占患者的14%）。未出现晶状体混浊或白内障形成。
使用激光间接检眼镜进行二极管激光光凝可安全用于伴有晶状体血管膜的眼睛。在我们研究中使用的激光能量水平下，未出现短暂性晶状体混浊或白内障形成。然而，本研究结果受患者数量相对较少和随访时间相对较短的限制。
