Seiberth V, Linderkamp O, Vardarli I, Knorz M C, Liesenhoff H
University Eye Hospital, Mannheim Hospitals, Clinical Medicine Faculty, University of Heidelberg, Germany.
Graefes Arch Clin Exp Ophthalmol. 1995 Aug;233(8):489-93. doi: 10.1007/BF00183430.
Laser photocoagulation in retinopathy of prematurity (ROP) appears to have fewer adverse effects than cryotherapy and seems to be at least as effective.
To evaluate the efficacy and safety of diode laser photocoagulation, we included 42 eyes with stage 3+ ROP of 24 preterm infants (gestational age 24-29 weeks, mean +/- SD 26.6 +/- 1.3 weeks; birth weight 480-1400 g, 896 +/- 196 g) in a prospective clinical study. Photocoagulation treatment was performed using a diode laser (810 nm) with a laser indirect ophthalmoscope delivery system. Follow-up ranged from 3 to 16 months (8.8 +/- 4.0 months).
In 39 (93%) of 42 eyes ROP regressed after a single laser treatment and the outcome was a flat, attached retina. One eye (2%) had a second laser session and another eye (2%) had additional retinal detachment surgery, resulting in the regression of ROP and a flat, attached retina. Thus, the success rate was 41 (98%) out of 42 eyes. In one (2%) of the 42 eyes treatment failed and ROP progressed to stage 5, although additional retinal detachment surgery was performed. No adverse side effects of diode laser treatment were noticed except for a small amount of retinal/preretinal bleeding in the ridge in five eyes (12%) and a small postoperative anterior chamber hemorrhage in one eye (2%) with dense tunica vasculosa lentis. Neither lenticular opacities nor cataract formation were encountered.
Diode laser photocoagulation for stage 3+ ROP showed only minor side effects and was at least as effective as cryotherapy treatment.
早产儿视网膜病变（ROP）的激光光凝治疗似乎比冷冻疗法的不良反应更少，且似乎至少同样有效。
为评估二极管激光光凝治疗的疗效和安全性，我们将24例早产儿（胎龄24 - 29周，平均±标准差26.6±1.3周；出生体重480 - 1400 g，896±196 g）的42只患有3+期ROP的眼睛纳入一项前瞻性临床研究。使用配备激光间接检眼镜输送系统的二极管激光（810 nm）进行光凝治疗。随访时间为3至16个月（8.8±4.0个月）。
42只眼中的39只（93%）在单次激光治疗后ROP消退，结果是视网膜变平并附着。1只眼（2%）进行了第二次激光治疗，另1只眼（2%）进行了额外的视网膜脱离手术，导致ROP消退且视网膜变平并附着。因此，42只眼中有41只（98%）成功。42只眼中有1只（2%）治疗失败，ROP进展至5期，尽管进行了额外的视网膜脱离手术。除了5只眼（12%）在嵴部出现少量视网膜/视网膜前出血以及1只眼（2%）因晶状体血管膜致密出现少量术后前房出血外，未发现二极管激光治疗的不良副作用。未遇到晶状体混浊或白内障形成。
二极管激光光凝治疗3+期ROP仅显示轻微副作用，且至少与冷冻疗法同样有效。
