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高剂量静脉注射环丙沙星在青年、老年以及男性和女性受试者中的药代动力学。

Pharmacokinetics of high-dose intravenous ciprofloxacin in young and elderly and in male and female subjects.

作者信息

Shah A, Lettieri J, Nix D, Wilton J, Heller A H

机构信息

Miles Inc., West Haven, Connecticut 06516, USA.

出版信息

Antimicrob Agents Chemother. 1995 Apr;39(4):1003-6. doi: 10.1128/AAC.39.4.1003.

DOI:10.1128/AAC.39.4.1003
PMID:7785969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162672/
Abstract

The effects of age and gender on the pharmacokinetics of high-dose intravenous ciprofloxacin in a healthy volunteer study were investigated. Plasma ciprofloxacin concentrations were higher in the elderly than in the young, and the pharmacokinetic parameters were not significantly different between the genders. Ciprofloxacin was well tolerated, with the majority of adverse events related to local reactions at the IV site.

摘要

在一项健康志愿者研究中，调查了年龄和性别对大剂量静脉注射环丙沙星药代动力学的影响。老年受试者血浆中环丙沙星浓度高于年轻受试者，且药代动力学参数在不同性别之间无显著差异。环丙沙星耐受性良好，大多数不良事件与静脉注射部位的局部反应有关。

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本文引用的文献

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Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia Study Group.住院患者重症肺炎的治疗：一项比较静脉注射环丙沙星与亚胺培南 - 西司他丁的多中心、随机、双盲试验结果。重症肺炎研究组
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