Stekar J, Hilgard P, Klenner T
Department of Experimental Cancer Research, ASTA Medica Aktiengesellschaft, Frankfurt am Main, Germany.
Eur J Cancer. 1995;31A(3):372-4. doi: 10.1016/0959-8049(94)00495-q.
The effect of pretreatment with miltefosine (MIL) on the antineoplastic activity of cyclophosphamide (CPA) was evaluated in subcutaneous benzo(a)pyrene-induced sarcomas (BPS) of the rat. MIL alone had no antineoplastic effect on this autochthonous tumour, but enhanced the chemotherapeutic effect of CPA. Conversely, MIL counteracted the myelotoxicity of CPA in normal adult rats. Although the nadir of the leucocyte count remained unchanged, the recovery phase was considerably shortened, an effect which resembled the pharmacological action of GM-CSF.
在大鼠皮下苯并(a)芘诱导的肉瘤（BPS）中评估了米替福新（MIL）预处理对环磷酰胺（CPA）抗肿瘤活性的影响。单独使用MIL对这种自发性肿瘤没有抗肿瘤作用，但增强了CPA的化疗效果。相反，MIL抵消了CPA对正常成年大鼠的骨髓毒性。虽然白细胞计数的最低点保持不变，但恢复阶段明显缩短，这一效果类似于粒细胞巨噬细胞集落刺激因子（GM-CSF）的药理作用。
