Barandun S, Morell A
Pathol Microbiol (Basel). 1975;42(4):302-11.
Prerequisites for immunobiological interactions between host and tumor are the existence of tumor-specific surface antigens on cancer cells on the one hand, and the ability of the host to recognize and to adequately respond to these signals on the other. It seems that in certain selected animal models these conditions are matched. The relations of the spontaneously arising human tumors to these prerequisites, however, are still largely obscure. It is known that immunological measures can both accelerate or inhibit tumor growth. Thus, immunoprophylaxis and immunotherapy in man is still premature and too risky.
宿主与肿瘤之间免疫生物学相互作用的前提条件,一方面是癌细胞上存在肿瘤特异性表面抗原,另一方面是宿主识别并充分响应这些信号的能力。在某些特定的动物模型中,似乎满足了这些条件。然而,人类自发产生的肿瘤与这些前提条件之间的关系仍大多不明。已知免疫措施既能加速也能抑制肿瘤生长。因此,人类的免疫预防和免疫治疗仍为时过早且风险太大。