Stevenson F K, Spellerberg M B, Chapman C J, Hamblin T J
Tenovus Laboratory, Southampton University Hospitals, U.K.
Leuk Lymphoma. 1995 Feb;16(5-6):379-84. doi: 10.3109/10428199509054423.
Selection of immunoglobulin variable region genes for recombination in B cells takes place from among those VH and VL gene segments available in the unrearranged germ line repertoire. In the case of neoplastic B cells, there is apparent deviation in the use of V-genes from that expected on a random basis, both for VH and for VL. Also, the preferred V-genes, and their patterns of mutation, differ among the various categories of B-cell tumor possibly reflecting the distinct origins and clonal histories on the individual tumor cells. This review focuses on a single VH gene, VH4-21, which is a member of the VH4 family, and which appears selectively to encode immunoglobulins with autoantibody activity, particularly anti-red cell antibodies. The pattern of usage of this VH gene by B-cell tumors demonstrates clear asymmetry among different tumor types. Also, the mutations detected in this relatively non-polymorphic gene indicate that antigen, possibly autoantigen, may influence the behavior of the tumor cell.
B细胞中用于重组的免疫球蛋白可变区基因是从未重排的种系基因库中可用的VH和VL基因片段中进行选择的。对于肿瘤性B细胞，VH和VL的V基因使用情况与随机预期情况存在明显偏差。此外，不同类别的B细胞肿瘤中偏好的V基因及其突变模式不同，这可能反映了各个肿瘤细胞的不同起源和克隆历史。本综述聚焦于单个VH基因VH4-21，它是VH4家族的成员，似乎选择性地编码具有自身抗体活性的免疫球蛋白，尤其是抗红细胞抗体。B细胞肿瘤对该VH基因的使用模式在不同肿瘤类型之间表现出明显的不对称性。此外，在这个相对非多态性的基因中检测到的突变表明，抗原，可能是自身抗原，可能会影响肿瘤细胞的行为。
