Tersariol I L, Ferreira T M, Medeiros M G, Porcionatto M A, Moraes C T, Abreu L R, Nader H B, Dietrich C P
Departamento de Bioquímica, Escola Paulista de Medicina, São Paulo, Brasil.
Braz J Med Biol Res. 1994 Sep;27(9):2097-102.
The sequence of the disaccharide units of eight heparan sulfate proteoglycans of different origins is described. All heparan sulfates contain 5 variable regions made of oligosaccharide blocks of disaccharides, namely, GlcUA(1-4)GlcNAc, GlcUA(1-4)GlcNS, IdoUA (1-4) GlcNS,6S,IdoUA-GlcNAc,6S, and IdoUA,2S(1-4)GlcNS,6S, besides two constant regions made of an internal tetrasaccharide (IdoUA-GlcNAc-IdoUA-GlcNS) and monosaccharides (GlcNS, and GlcNS,6S) at the non-reducing terminal. The N-acetylated region of the heparan sulfates is linked to the serine of the protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfates differ from one another in terms of the number of disaccharides that compose each block.
描述了八种不同来源的硫酸乙酰肝素蛋白聚糖中二糖单元的序列。所有硫酸乙酰肝素都包含由二糖寡糖块组成的5个可变区域，即GlcUA(1-4)GlcNAc、GlcUA(1-4)GlcNS、IdoUA(1-4)GlcNS,6S、IdoUA-GlcNAc,6S和IdoUA,2S(1-4)GlcNS,6S，此外还有由内部四糖(IdoUA-GlcNAc-IdoUA-GlcNS)和非还原末端的单糖(GlcNS和GlcNS,6S)组成的两个恒定区域。硫酸乙酰肝素的N-乙酰化区域通过Xyl-Gal-Gal三糖与蛋白核心的丝氨酸相连。硫酸乙酰肝素在组成每个块的二糖数量方面彼此不同。
