Elias M C, Chammas R, Giorgi R R, Frochtengarten F, Santos C L, Brentani R R
Instituto Ludwig de Pesquisa sobre o Câncer, São Paulo, Brasil.
Braz J Med Biol Res. 1994 Sep;27(9):2181-4.
F9 mouse teratocarcinoma cells have a high capacity to adhere to laminin and we identified alpha 6/beta 1 integrin as the principal laminin-binding protein present in these cells. F9 cells differentiated into parietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to laminin was observed due to a lower expression of alpha 6/beta 1 integrin on the cell surface.
F9小鼠畸胎癌细胞具有很高的与层粘连蛋白结合的能力，我们鉴定出α6/β1整合素是这些细胞中主要的层粘连蛋白结合蛋白。当单层培养的F9细胞用视黄酸和二丁酰环磷腺苷处理时，它们会分化为壁内胚层。在这个过程中，由于细胞表面α6/β1整合素的表达降低，观察到与层粘连蛋白的粘附减少。
