Jones D P, Chesney R W
Department of Pediatrics, University of Tennessee, Memphis 38103, USA.
Curr Opin Pediatr. 1995 Apr;7(2):208-13. doi: 10.1097/00008480-199504000-00016.
Ifosfamide and cisplatin are two commonly used cancer chemotherapeutic agents associated with significant acute and chronic renal toxicity. The clinical characteristics of ifosfamide-induced renal injury are proximal tubular wasting of glucose, phosphate, bicarbonate, sodium, potassium, and amino acids; proteinuria; and decreased glomerular filtration rate. Cisplatin administration may result in a dose-dependent reduction of glomerular filtration rate, hypomagnesemia, hypokalemia, and polyuria. The characteristics of renal toxicity associated with each of these agents are discussed with attention to possible mechanisms of injury and long-term clinical outcome.
异环磷酰胺和顺铂是两种常用的癌症化疗药物，它们会导致显著的急慢性肾毒性。异环磷酰胺所致肾损伤的临床特征为近端肾小管对葡萄糖、磷酸盐、碳酸氢盐、钠、钾和氨基酸的排泄增加；蛋白尿；以及肾小球滤过率降低。使用顺铂可能导致肾小球滤过率呈剂量依赖性降低、低镁血症、低钾血症和多尿。本文将讨论与这两种药物相关的肾毒性特征，并关注可能的损伤机制和长期临床结局。
