Lagrange P H, Fourgeaud M, Neway T, Pilet C
Service de microbiologie, Hôpital Saint-Louis, Paris, France.
C R Acad Sci III. 1995 Mar;318(3):359-65.
Intraperitoneal administration of polar glycopeptidolipids extracted from Mycobacterium chelonae (pGPL-Mc) greatly increased the resistance of mice against a lethal disseminated Candida albicans infection. This enhanced resistance was demonstrated by an increase in the number of survivors and the prolongation of the mean survival time of animals following a lethal challenge. These effects were dependent upon the infective dose of Candida albicans, the dose of pGPL-Mc and the timing of its administration. This enhanced resistance was correlated with the development and persistence of a hyperleukocytosis, associated with a long lasting increase in the number of polymorphonuclear neutrophils. On the contrary, no candidacidal effect of the serum collected from pretreated mice was observed; suggesting that the ability of pGPL-Mc to increase resistance against Candida albicans infection is likely to be mediated by polymorphonuclear neutrophils. These results confirm previously described immunostimulating properties of pGPL-Mc and open the way for the evaluation of its effect in the prevention of opportunistic infections in neutropenic patients.
腹腔注射从龟分枝杆菌中提取的极性糖肽脂（pGPL-Mc）可显著增强小鼠对致死性播散性白色念珠菌感染的抵抗力。致死性攻击后，存活小鼠数量增加以及动物平均存活时间延长证明了这种抵抗力的增强。这些效应取决于白色念珠菌的感染剂量、pGPL-Mc的剂量及其给药时间。这种抵抗力的增强与白细胞增多症的发展和持续存在相关，伴随着多形核中性粒细胞数量的长期增加。相反，未观察到从预处理小鼠收集的血清具有杀念珠菌作用；这表明pGPL-Mc增强抗白色念珠菌感染能力可能是由多形核中性粒细胞介导的。这些结果证实了先前描述的pGPL-Mc的免疫刺激特性，并为评估其在预防中性粒细胞减少患者机会性感染中的作用开辟了道路。
