地塞米松可募集大鼠左心房和心室心尖处的心房利钠肽分泌细胞。

Dexamethasone recruits atrial natriuretic peptide secretory cells in the rat left atrium and apex of the ventricle.

作者信息

Miller H A, Haste J, Carpenter T, Maulden S

机构信息

Department of Biological Sciences, East Tennessee State University, Johnson City 37601-0703, USA.

出版信息

Mol Cell Endocrinol. 1995 Mar;109(1):63-7. doi: 10.1016/0303-7207(95)03486-q.

DOI:10.1016/0303-7207(95)03486-q

PMID:7789616

Abstract

The response of the atrial natriuretic peptide (ANP) secreting cells from both rat atria and the apex of the ventricles to dexamethasone (DEX) was analyzed by the plaque assay. In right atrial cardiocytes, 25% of the cells secreted ANP basally; DEX treatment did not alter this percentage. However, in the left atrial secretory population, a discordance between the basal (15%) and DEX stimulated (25%) percent plaque formation was found. ANP secreting cells from the ventricular apex responded similarly to DEX exposure (26%), with 8% of the cells basally releasing the hormone. These data suggest that in both the left atria and apex of the rat ventricles, exposure to DEX recruits ANP secretory cells from a non-secreting population. Consequently, the release of ANP from these tissues would increase after glucocorticoid stimulation.

摘要

通过蚀斑分析对来自大鼠心房和心室心尖的心房利钠肽（ANP）分泌细胞对地塞米松（DEX）的反应进行了分析。在右心房心肌细胞中，25%的细胞基础分泌ANP；DEX处理并未改变这一百分比。然而，在左心房分泌群体中，发现基础蚀斑形成百分比（15%）和DEX刺激后蚀斑形成百分比（25%）之间存在差异。来自心室心尖的ANP分泌细胞对DEX暴露的反应类似（26%），8%的细胞基础释放该激素。这些数据表明，在大鼠左心房和心室心尖中，暴露于DEX会从非分泌群体中募集ANP分泌细胞。因此，糖皮质激素刺激后这些组织中ANP的释放将会增加。