人（ZNF147）和小鼠雌激素反应性指蛋白（Efp）基因的染色体定位，Efp是环指蛋白家族的一员。

Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family.

作者信息

Inoue S, Orimo A, Matsuda Y, Inazawa J, Emi M, Nakamura Y, Hori T, Muramatsu M

机构信息

Department of Biochemistry, Saitama Medical School, Japan.

出版信息

Genomics. 1995 Jan 20;25(2):581-3. doi: 10.1016/0888-7543(95)80064-s.

DOI:10.1016/0888-7543(95)80064-s

PMID:7789997

Abstract

We have previously identified an estrogen-responsive gene, efp (estrogen-responsive finger protein), that encodes a putative zinc finger protein (Proc. Natl. Acad. Sci. USA 90: 11117-11121, 1993). The efp protein has a RING finger, a variant type of zinc finger motif, B1 box, and B2 box, each having a pair of zinc fingers, present in a family of apparent DNA-binding proteins. Some members of this family have transformation capabilities when found in chromosomal translocations. Chromosome mapping of the efp gene by fluorescence in situ hybridization reveals that human EFP (ZNF147) is located at 17q23.1 and that mouse Efp is located at 11C. These results provide additional evidence that the mouse 11C region displays conserved synteny with the 17q23.1 region of the human genome.

摘要

我们之前鉴定出了一个雌激素反应基因efp（雌激素反应性指蛋白），它编码一种假定的锌指蛋白（《美国国家科学院院刊》90: 11117 - 11121, 1993）。efp蛋白具有一个RING指结构，这是锌指基序的一种变体类型，还有B1框和B2框，每个框都有一对锌指，存在于一组明显的DNA结合蛋白家族中。该家族的一些成员在染色体易位时具有转化能力。通过荧光原位杂交对efp基因进行染色体定位显示，人类EFP（ZNF147）位于17q23.1，而小鼠Efp位于11C。这些结果提供了额外的证据，表明小鼠11C区域与人类基因组的17q23.1区域显示出保守的同线性。