Xiao S, McGill K C, Hentz V R
Rehabilitation Research and Development Center, VA Medical Center, Palo Alto, CA 94304-1200, USA.
IEEE Trans Biomed Eng. 1995 Jun;42(6):599-607. doi: 10.1109/10.387199.
Previous simulations of volume-conducted nerve-fiber action-potentials have modeled the limb as semi-infinite or circularly cylindrical, and the fibers as straight lines parallel to the limb surface. The geometry of actual nerves and limbs, however, can be considerably more complicated. This paper presents a general method for computing the potentials of fibers with arbitrary paths in arbitrary finite limbs. It involves computing the propagating point-source response (PPSR), which is the potential arising from a single point source (dipole or tripole) travelling along the fiber. The PPSR can be applied to fibers of different conduction velocities by simple dilation or compression. The method is illustrated for oblique and spiralling nerve fibers. Potentials from oblique fibers are shown to be different for orthodromic and antidromic propagation. Such results show that the straight-line models are not always adequate for nerves with anatomical amounts of curvature.
先前对容积传导神经纤维动作电位的模拟，将肢体建模为半无限长或圆柱形，将纤维建模为平行于肢体表面的直线。然而，实际神经和肢体的几何形状可能要复杂得多。本文提出了一种通用方法，用于计算任意有限肢体中具有任意路径的纤维的电位。该方法涉及计算传播点源响应（PPSR），即由沿纤维移动的单个点源（偶极子或三极子）产生的电位。通过简单的扩张或压缩，PPSR可应用于不同传导速度的纤维。本文针对斜向和螺旋状神经纤维对该方法进行了说明。结果表明，斜向纤维的电位在顺向和逆向传播时有所不同。这些结果表明，直线模型对于具有解剖学曲率的神经并不总是适用的。
