白细胞介素-6在单核细胞增生李斯特菌初次和二次感染期间T细胞活化中的作用。
Role of interleukin-6 in T-cell activation during primary and secondary infection with Listeria monocytogenes.
作者信息
Liu Z, Simpson R J, Cheers C
机构信息
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Infect Immun. 1995 Jul;63(7):2790-2. doi: 10.1128/iai.63.7.2790-2792.1995.
Abstract
Injection of recombinant interleukin-6 (IL-6) into mice enhances recovery from infection with Listeria monocytogenes. In this study, the role of IL-6 during primary and secondary Listeria infection was further tested. Neutralization of IL-6 by polyclonal antibody exacerbated primary infection and significantly delayed gamma interferon production by cultured spleen cells. In contrast, administration of anti-IL-6 antibody at the time of secondary infection did not affect the recovery of mice from infection or gamma interferon production, showing that activated T cells are not dependent on IL-6.
摘要
向小鼠注射重组白细胞介素-6（IL-6）可增强其从单核细胞增生李斯特菌感染中恢复的能力。在本研究中，进一步检测了IL-6在原发性和继发性李斯特菌感染中的作用。用多克隆抗体中和IL-6会加重原发性感染，并显著延迟培养的脾细胞产生γ干扰素。相比之下，在继发性感染时给予抗IL-6抗体并不影响小鼠从感染中恢复或γ干扰素的产生，这表明活化的T细胞不依赖于IL-6。
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Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.一种对B细胞杂交瘤具有生长因子活性的T细胞衍生淋巴因子的纯化及氨基末端氨基酸序列分析
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