Mimouni F, Mughal Z, Tsang R C, Hammond G
Department of Pediatrics, Maimonides Medical Center, Brooklyn, New York 11219, USA.
J Am Coll Nutr. 1995 Apr;14(2):165-8. doi: 10.1080/07315724.1995.10718489.
We tested the hypothesis that continuous maternal oxygen (O2) therapy leads to an increase in fetal survival, improvement in fetal growth, and correction of decreased placental calcium (Ca) transport, in pregnant rats who underwent uterine artery ligation.
We measured on Day 21 of pregnancy, the unidirectional maternofetal clearance of 45Ca (Kmf45Ca) and 51Cr-EDTA (Kmf51Cr-EDTA) across in-situ perfused placentas of rats randomized on Day 17 to a modified Wigglesworth (bilateral uterine artery ligation) procedure (group WW, n = 8), to modified Wigglesworth and supplemental maternal O2 treatment (FiO2 0.40) (group WWO2, n = 8), or to a sham operation (group Sh, n = 8). Kmf51Cr-EDTA provides a measure of placental "porosity" or passive permeability.
Maternal O2 therapy did not improve fetal survival, fetal growth, or placental Ca transport. CONCLUSION AND SPECULATION: Bilateral uterine ligation in the pregnant rat leads to IUGR and decreased placental Ca transport which cannot be corrected by maternal O2 therapy.
我们验证了这样一个假设，即在接受子宫动脉结扎的怀孕大鼠中，持续的母体氧气（O₂）治疗可提高胎儿存活率、改善胎儿生长并纠正胎盘钙（Ca）转运减少的情况。
在妊娠第21天，我们测量了在第17天随机接受改良威格尔斯沃思手术（双侧子宫动脉结扎）（WW组，n = 8）、改良威格尔斯沃思手术加母体补充氧气治疗（FiO₂ 0.40）（WWO₂组，n = 8）或假手术（Sh组，n = 8）的大鼠原位灌注胎盘上45Ca（Kmf45Ca）和51Cr - EDTA（Kmf51Cr - EDTA）的单向母胎清除率。Kmf51Cr - EDTA可衡量胎盘的“孔隙率”或被动通透性。
母体氧气治疗并未改善胎儿存活率、胎儿生长或胎盘钙转运。结论与推测：怀孕大鼠的双侧子宫结扎会导致宫内生长受限和胎盘钙转运减少，而母体氧气治疗无法纠正这种情况。
