Zoubos A B, Soucacos P N, Seaber A V, Urbaniak J R
The 1st Orthopaedic Department, University of Athens Medical School, Greece.
Int Angiol. 1994 Dec;13(4):336-8.
A main consideration of microvascular surgery is the avoidance of thrombosis. This traditionally involves the avoidance of thrombogenic trauma, the establishment of normal blood flow and full vessel diameter, as well as the use of anticoagulants, such as heparin, as an antithrombotic measure. In the present study we assessed the effectiveness of heparin in maintaining patency in the femoral arteries of rats which have undergone a crush injury with damage to the intima and media layers of the wall. To accomplish this, the animals were treated with heparin 150 units or 300 units twice daily following microvascular repair using standard microsurgical techniques. Control animals received no treatment. The results of this study indicate that the number of patencies in experimentally-injured femoral arteries did not improve significantly following heparin treatment, although pharmacological doses of heparin (300 units twice daily) were associated with a somewhat lower rate of occlusions. We conclude that heparin appears unable to significantly prevent clotting in vessels which have experienced severe trauma to the intima and media layers.
微血管手术的一个主要考量因素是避免血栓形成。传统上，这包括避免产生血栓形成的创伤、建立正常的血流和血管的完整直径，以及使用抗凝剂（如肝素）作为抗血栓措施。在本研究中，我们评估了肝素对经历挤压伤且血管壁内膜和中膜层受损的大鼠股动脉维持通畅的有效性。为实现这一目的，在使用标准显微外科技术进行微血管修复后，每天给动物两次注射150单位或300单位的肝素。对照动物不接受治疗。本研究结果表明，尽管给予药理剂量的肝素（每天两次，每次300单位）会使闭塞率有所降低，但肝素治疗后，实验性损伤的股动脉通畅数量并未显著改善。我们得出结论，肝素似乎无法显著预防内膜和中膜层遭受严重创伤的血管内的凝血。
