Zuppa A A, Mazzotta M, Maragliano G, Girlando P, Florio M G, Tortorolo G
Istituto di Clinica Pediatrica, Università Cattolica del Sacro Cuore, Roma.
Minerva Pediatr. 1995 Jan-Feb;47(1-2):13-8.
To investigate the importance of transfusion practice with packed red cells (PRCs) in premature infants and to identify risk factors significant influencing transfusion practice, we analyzed 75 preterm infants (gestational age: 31 +/- 2 weeks; birth weight: 1459 +/- 402 g) admitted to the neonatal intensive care unit of Catholic University of Rome. Fifty-three (70.7%) of the infants received one or more PRCs transfusions (in total 246 transfusions). The variables associated with an increase in number and frequency of PRCs transfusions were: a) gestational age < or = 30 weeks; b) birth weight < or = 1000 g; c) severe neonatal pathology (ie a respiratory disease requiring ventilatory support and/or a clearly documented or suspected sepsis). Repeated PRCs transfusions during the first week of life significantly (p < 0.01) influenced the need for late transfusions, after 4 weeks of age, for the treatment of the anemia of prematurity. These data indicate that preterm infants with a gestational age < or = 30 weeks, a birth weight < 1000 g and a severe respiratory or infectious disease represent natural candidates for administration of recombinant human erythropoietin to reduce the need for late PRCs transfusions.
为了研究早产儿输注浓缩红细胞（PRCs）的重要性，并确定显著影响输血实践的风险因素，我们分析了罗马天主教大学新生儿重症监护病房收治的75例早产儿（胎龄：31±2周；出生体重：1459±402g）。其中53例（70.7%）婴儿接受了一次或多次PRCs输血（共246次输血）。与PRCs输血次数和频率增加相关的变量有：a）胎龄≤30周；b）出生体重≤1000g；c）严重的新生儿疾病（即需要通气支持的呼吸系统疾病和/或明确记录或疑似的败血症）。出生后第一周重复输注PRCs对4周龄后治疗早产儿贫血的后期输血需求有显著影响（p<0.01）。这些数据表明，胎龄≤30周、出生体重<1000g且患有严重呼吸系统或感染性疾病的早产儿是使用重组人促红细胞生成素以减少后期PRCs输血需求的自然候选者。
