Chiaravalloti G, Baracchini A, Rossomando V, Ughi C, Ceccarelli M
Instituto di Clinica Pediatrica, Università degli Studi di Pisa.
Minerva Pediatr. 1995 Jan-Feb;47(1-2):23-6.
The authors describe a case of association cystic fibrosis coeliac disease, which they have observed. The frequency of this association in the general population is of 1:2,000,000. M.A. presents little growth in terms of height and weight and intestinal alterations (an abundance of fatty and mucous stool). The initial diagnosis was that of coeliac disease. After two months of diet without gluten one observed an increase in weight, but o result for the intestinal disturbances. The positive result revealed from the sweat-test and the study of genomic mutation (delta F508) showed the diagnosis of cystic fibrosis associated with coeliac disease. The specific treatment of both syndromes resolved intestinal alterations and caused the diminution of the acute bronchitis frequent during the first and the second infancy.
作者描述了他们所观察到的一例囊性纤维化合并乳糜泻的病例。这种关联在普通人群中的发生率为1:2,000,000。M.A.在身高和体重方面几乎没有增长，并且有肠道改变（大量脂肪性和黏液性粪便）。最初的诊断是乳糜泻。在无麸质饮食两个月后，体重有所增加，但肠道紊乱问题没有改善。汗液测试的阳性结果以及基因突变（ΔF508）研究显示诊断为囊性纤维化合并乳糜泻。两种综合征的特异性治疗解决了肠道改变问题，并减少了婴儿期头两年频繁出现的急性支气管炎。
