Christensen K, Schmidt M M, Vaeth M, Olsen J
Danish Epidemiology Science Center research unit, Steno Institute of Public Health, Aarhus.
N Engl J Med. 1995 Jul 20;333(3):161-4. doi: 10.1056/NEJM199507203330305.
The rate of recurrence of a broad range of birth defects may decrease among women who change residence after the birth of their first infant. The aim of the present study was to determine the effect of changing residence on the recurrence of congenital facial-cleft defects.
We identified 4189 women who had infants with facial-cleft defects by linking a data base comprising the records of children with facial clefts born between 1952 and 1987 with the Central Person Registry in Denmark. Among the 4189 mothers, 1902 each had additional children after the first child with a facial-cleft defect. A total of 2692 younger siblings were identified. We compared the proportion of infants with facial-cleft defects among the younger siblings between mothers who had changed municipalities or sexual partners and those who had not.
Changing the municipality of residence did not decrease the frequency with which facial-cleft defects recurred in younger siblings. Among the 907 infants of mothers who changed municipalities but not partners, 29 (3.2 percent) had facial-cleft defects, as compared with 48 (3.4 percent) of 1425 infants of mothers who changed neither municipality nor partner (relative risk, 0.9; 95 percent confidence interval, 0.6 to 1.5). However, a change of partner reduced the recurrence risk significantly. Among 236 infants of mothers who changed partners, 1 (0.4 percent) had a facial-cleft defect, as compared with 77 (3.3 percent) of 2350 infants of mothers who did not change partners (relative risk, 0.1; 95 percent confidence interval, 0.02 to 0.9).
Recurrence of facial-cleft defects is not linked to the residence of the mother, but having a different partner reduced a woman's risk of having a second child with this defect.
在生育第一个婴儿后更换居住地的女性中，多种出生缺陷的复发率可能会降低。本研究的目的是确定更换居住地对先天性面部裂缺陷复发的影响。
通过将一个包含1952年至1987年间出生的面部裂患儿记录的数据库与丹麦中央人口登记处相链接，我们识别出4189名生育了面部裂缺陷患儿的女性。在这4189名母亲中，有1902名在第一个孩子出现面部裂缺陷后又生育了其他孩子。共识别出2692名弟弟妹妹。我们比较了更换市政当局或性伴侣的母亲与未更换的母亲的弟弟妹妹中面部裂缺陷婴儿的比例。
更换居住市政当局并未降低弟弟妹妹中面部裂缺陷的复发频率。在更换市政当局但未更换伴侣的母亲所生的907名婴儿中，有29名（3.2%）出现面部裂缺陷，而在既未更换市政当局也未更换伴侣的母亲所生的1425名婴儿中，有48名（3.4%）出现面部裂缺陷（相对风险，0.9；95%置信区间，0.6至1.5）。然而，更换伴侣显著降低了复发风险。在更换伴侣的母亲所生的236名婴儿中，有1名（0.4%）出现面部裂缺陷，而在未更换伴侣的母亲所生的2350名婴儿中，有77名（3.3%）出现面部裂缺陷（相对风险，0.1；95%置信区间，0.02至0.9）。
面部裂缺陷的复发与母亲的居住地无关，但更换伴侣可降低女性生育第二个患有此缺陷孩子的风险。
