Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.
作者信息
Matyja E, Szmielew A, Khaspekov L, Victorov I
机构信息
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
出版信息
Neuropatol Pol. 1993;31(3-4):133-41.
PMID:7792010
Abstract
The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.
摘要
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