低剂量喹啉酸诱导的海马解离培养神经元损伤的超微结构评估
Ultrastructural evaluation of neuronal damages induced by low doses of quinolinic acid in dissociated hippocampal culture.
作者信息
Matyja E, Szmielew A, Khaspekov L, Victorov I
机构信息
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
出版信息
Neuropatol Pol. 1993;31(3-4):133-41.
The effect of a subtoxic level of quinolinic acid (QUIN) on the morphological picture of the rat hippocampus in dissociated cultures was investigated. Addition of 50 microM of QUIN to the culture medium induced only slight advanced and reversible changes of the postsynaptic elements, whereas the majority of pyramidal neurons were undamaged. The results suggest that subtoxic concentration of QUIN is insufficient to produce stable depolarization of cell membranes and severe neuronal damage.
研究了亚毒性水平的喹啉酸（QUIN）对离体培养的大鼠海马形态学图像的影响。向培养基中添加50微摩尔的QUIN仅诱导突触后元件出现轻微的、进展性且可逆的变化，而大多数锥体神经元未受损。结果表明，亚毒性浓度的QUIN不足以使细胞膜产生稳定的去极化以及造成严重的神经元损伤。
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