Sorg O, Pellerin L, Stolz M, Beggah S, Magistretti P J
Laboratoire de Recherche Neurologique, Institut de Physiologie et Service de Neurologie du CHUV, Faculté de Médecine, Université de Lausanne, Switzerland.
Neurosci Lett. 1995 Mar 24;188(2):109-12. doi: 10.1016/0304-3940(95)11410-x.
Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 microM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP. Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 microM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.
三磷酸腺苷（ATP）可促进原代培养的小鼠大脑皮质星形胶质细胞中的糖原分解，其半数有效浓度（EC50）为1.5微摩尔。药理学分析表明嘌呤能P2Y受体参与了ATP的这一作用。应用花生四烯酸（AA）或某些不饱和脂肪酸也会导致糖原分解。AA的EC50约为50微摩尔。因此，ATP和AA可以被列入控制星形胶质细胞中糖原水平的神经活性物质清单，该清单还包括去甲肾上腺素、血管活性肠肽（VIP）、腺苷和组胺。
