猫肺弥漫性神经内分泌系统中7B2的时空分布。

Spatial and temporal distribution of 7B2 in the pulmonary diffuse neuroendocrine system of the cat.

作者信息

Seldeslagh K A, Lauweryns J M

机构信息

Catholic University of Louvain, Faculty of Medicine, Laboratory for Histopathology, Belgium.

出版信息

Neurosci Lett. 1995 Mar 24;188(2):85-8. doi: 10.1016/0304-3940(95)11402-i.

DOI:10.1016/0304-3940(95)11402-i

PMID:7792063

Abstract

The postnatal developmental profile of the presence of 7B2 was studied immunocytochemically in the pulmonary diffuse neuroendocrine system of the cat. Labelling was found in neuroepithelial bodies (NEB) but not in solitary neuroendocrine cells. The identity of NEB was confirmed on adjacent serial sections by the immunostaining for protein gene product 9.5, a pan-neuroendocrine marker. The first 3 weeks after birth 7B2 stained NEB were most abundant with a subsequent decline thereafter. The positive correlation between the variation of 7B2 immunoreactivity and number of NEB suggests an important role for 7B2 in NEB.

摘要

采用免疫细胞化学方法研究了猫肺弥漫性神经内分泌系统中7B2表达的产后发育情况。在神经上皮小体（NEB）中发现有标记，但在孤立神经内分泌细胞中未发现。通过对泛神经内分泌标志物蛋白基因产物9.5进行免疫染色，在相邻连续切片上证实了NEB的特征。出生后的前3周，7B2染色的NEB最为丰富，此后逐渐减少。7B2免疫反应性变化与NEB数量之间的正相关表明7B2在NEB中起重要作用。