Hake R, Eckel H, von Pritzbuer E, Volling P, Thiele J
Institut für Pathologie, Universität zu Köln.
Pathologe. 1995 May;16(3):197-203. doi: 10.1007/s002920050091.
An immunohistochemical analysis with monoclonal antibodies against Ki-67 (MIB 1), PCNA (PC10), p53 and Lewis X antigen was performed on 47 squamous carcinomas of the larynx after partial laser resection. Ki-67 index and expression of Lewis X antigen correlated significantly with both tumor recurrence rate and tumor-free interval. A much weaker relationship was found for the expression of proliferating cell nuclear antigen (PCNA), and no correlation existed with p53 expression. In conclusion, examination of Ki-67 and Lewis X antigen is thought to provide useful prognostic information concerning laser-resectable squamous carcinomas of the larynx.
对47例喉鳞状细胞癌患者行部分激光切除术后，采用抗Ki-67（MIB 1）、增殖细胞核抗原（PCNA，PC10）、p53和Lewis X抗原的单克隆抗体进行免疫组化分析。Ki-67指数和Lewis X抗原的表达与肿瘤复发率和无瘤间期均显著相关。增殖细胞核抗原（PCNA）表达的相关性较弱，与p53表达无相关性。总之，检测Ki-67和Lewis X抗原被认为可为激光可切除的喉鳞状细胞癌提供有用的预后信息。
