Grob P J, Joller-Jemelka H I
Abteilung für Klinische Immunologie, Universitätsspital Zürich.
Praxis (Bern 1994). 1995 May 9;84(19):547-54.
Until today only five pathogens of viral hepatitis have been discovered: hepatitis virus A (HAV), B (HBV), C (HCV), D (HDV) and E (HEV). An update on the state of the art of actually established diagnostic procedures is briefly summarized. Some recent topics and problems are covered more extensively; in the case of HBV the value of HBsAG concentration as a prognostic marker, the finding 'anti-HBc only' the role of HBV mutants, the determination of circulating HBV genomic material, and modalities for HBV vaccination control; in the case of HCV the indications for study of its viral genomic material and the role of HCV subspecies are explained. Finally, first results on HEV prevalence in Switzerland are introduced.
直到今天，仅发现了五种病毒性肝炎病原体：甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、丁型肝炎病毒（HDV）和戊型肝炎病毒（HEV）。本文简要总结了目前实际应用的诊断方法的最新进展。对一些近期的主题和问题进行了更广泛的探讨；对于HBV，讨论了HBsAG浓度作为预后标志物的价值、“仅抗HBc”的发现、HBV突变体的作用、循环HBV基因组物质的测定以及HBV疫苗接种控制方式；对于HCV，解释了研究其病毒基因组物质的指征以及HCV亚型的作用。最后，介绍了瑞士HEV流行率的初步结果。
