[House fly development after chitin biosynthesis inhibitor application to eggs].

Nine asymmetrically substituted ureas were bioassayed against house-fly (Musca domestica L.) eggs. The compounds included benzoylaryl urea derivatives, shown in Table I, (compounds 1 and 3-8) and benzoylheteroaryl ureas (2 and 9) which previously revealed effective inhibition of metamorphosis and reproduction when applied in food to the larvae and adults. The benzoyl moiety of the compounds comprise 2,6-disubstituted benzene ring with fluorine atoms (6-9), chlorine atoms (1-2) or fluorine and chlorine atoms (3-5), respectively. The majority of the compounds include aniline derivatives (1, 3-8), except the two containing pyridine ring (2) or pyridone-2 system (9). The eggs of house fly Musca domestica L. (some hours after they were laid) were put on a piece of cloth impregnated with acetone solution of tested compounds in concentrations 0.1 and 0.01%. The hatching of larvae and the later phases of development were observed. From the tested compounds one (no 8 in tab. II) decreased and delayed the hatching, two compounds (no 1 and 4 in tab. II) affected the later stages of development: the number of pupae and adults were decreased.