一种新型非甾体类抗风湿药物的初步研究结果（作者译）
[Preliminary results with a new non-steroidal antirheumatic drug (author's transl)].
作者信息
Frank O, Klicpera M, Kolarz G, Scherak O
出版信息
Wien Klin Wochenschr. 1975 Jun 27;87(13):427.
PMID:779281
Abstract
Thirty patients with classical or definite rheumatoid arthritis were treated over a 4-week period with diftalone, a new non-steroidal antirheumatic drug. The daily dosage ranged from 500 to 1000 mg. A good objective response was achieved in 69% of the patients. Diftalone was well tolerated. Side effects were noted in 11.8% of patients on 500 mg diftalone daily and in 18.8% of cases treated with the highest dosage (1000 mg daily). The optimum daily dosage appears to be 750 mg.
摘要
30例典型或确诊类风湿性关节炎患者在4周内接受了新型非甾体类抗风湿药二氟尼柳治疗。日剂量为500至1000毫克。69%的患者获得了良好的客观反应。二氟尼柳耐受性良好。每日服用500毫克二氟尼柳的患者中11.8%出现副作用，最高剂量（每日1000毫克）治疗的病例中18.8%出现副作用。最佳日剂量似乎为750毫克。
相似文献
1
[Preliminary results with a new non-steroidal antirheumatic drug (author's transl)].一种新型非甾体类抗风湿药物的初步研究结果（作者译）
Wien Klin Wochenschr. 1975 Jun 27;87(13):427.
2
Therapeutic activity of diftalone in rheumatoid arthritis: a short-term controlled evaluation.
Int J Clin Pharmacol. 1974 Dec;10(4):239-54.
3
4
Therpaeutic value of a new antirheumatic drug.一种新型抗风湿药物的治疗价值。
Rev Roum Med. 1974;12(2):97-102.
5
The therapeutic activity of diftalone in rheumatoid arthritis: crossover comparison with indomethacin.双他氯在类风湿性关节炎中的治疗活性：与吲哚美辛的交叉比较。
Curr Med Res Opin. 1975;3(2):109-20. doi: 10.1185/03007997509113657.
6
Diftalone: a new non-steroidal anti-inflammatory agent: comparative study with phenylbutazone in the treatment of rheumatoid arthritis.双氟尼酸：一种新型非甾体抗炎药：与保泰松治疗类风湿性关节炎的对比研究。
J Int Med Res. 1977;5(1):18-25. doi: 10.1177/030006057700500103.
7
Antiinflammatory activity and other pharmacological properties of phthalazino(2,3-b)phthalazine-5,12(7H, 14H)-dione (Diftalone).
Arzneimittelforschung. 1974 Dec;24(12):2003-9.
8
Plasma levels of diftalone during treatment and their relationship with therapeutic activity in rheumatoid arthritis.类风湿关节炎治疗期间双醋瑞因的血浆水平及其与治疗活性的关系。
Int J Clin Pharmacol. 1974 Dec;10(4):255-65.
9
[Sulindac: Clinical test of a new antiinflammatory agent in rheumatoid arthritis (author's transl)].
Wien Klin Wochenschr Suppl. 1976;59:1-10.
10
Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis.
Q J Med. 1973 Apr;42(166):387-401.
Zotero 插件