脱氢表雄酮对诱导性高胆固醇血症家兔血清脂质、胰岛素和性激素水平的影响。
The influence of DHEA on serum lipids, insulin and sex hormone levels in rabbits with induced hypercholesterolemia.
作者信息
Bednarek-Tupikowska G, Milewicz A, Kossowska B, Bohdanowicz-Pawlak A, Sciborski R
机构信息
Department of Endocrinology, Medical Academy, Wroclaw, Poland.
出版信息
Gynecol Endocrinol. 1995 Mar;9(1):23-8. doi: 10.3109/09513599509160187.
The authors estimated the influence of dehydroepiandrosterone (DHEA) administration, a potential antiatherogenic agent, on serum lipids, sex hormones and insulin levels in male rabbits fed on an atherogenic diet. They concluded that (1) DHEA administration has an unfavorable impact on the serum lipid profile; (2) an atherogenic diet causes insulin resistance; (3) the glucose and insulin levels are not related to DHEA in normally fed rabbits and in rabbits with hyperlipoproteinemia; (4) an atherogenic diet causes a slight increase of estradiol concentration; (5) DHEA treatment has no significant effect on testosterone and estradiol concentrations in both normally fed rabbits and those on an atherogenic diet; (6) DHEA administration has an anti-obesity effect.
作者评估了给予脱氢表雄酮（DHEA）——一种潜在的抗动脉粥样硬化剂，对食用致动脉粥样硬化饮食的雄性兔子的血脂、性激素和胰岛素水平的影响。他们得出结论：（1）给予DHEA对血清脂质谱有不利影响；（2）致动脉粥样硬化饮食会导致胰岛素抵抗；（3）正常喂养的兔子和患有高脂蛋白血症的兔子的血糖和胰岛素水平与DHEA无关；（4）致动脉粥样硬化饮食会导致雌二醇浓度略有升高；（5）DHEA治疗对正常喂养的兔子和食用致动脉粥样硬化饮食的兔子的睾酮和雌二醇浓度均无显著影响；（6）给予DHEA有抗肥胖作用。
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