Althaus M, Vink H J, Minderaa R B, Goorhuis-Brouwer S M, Oosterhoff M D
University Center of Child and Adolescent Psychiatry, Groningen, The Netherlands.
Am J Psychiatry. 1995 Jul;152(7):1087-9. doi: 10.1176/ajp.152.7.1087.
The authors studied the effects of the alpha 2-receptor agonist clonidine on stuttering in children.
Using a double-blind crossover study, they gave placebo or 4 micrograms/kg body weight per day to 25 stuttering children who were 6-13 years old. Stuttering was measured by counting the occurrences of four elementary speech difficulties and by asking parents and teachers to give an overall impression of the amount of stuttering, as well as their impression of how troublesome the stuttering was to the children.
Clonidine did not improve stuttering.
Clonidine cannot be recommended as a useful drug for treating children who stutter.
作者研究了α2受体激动剂可乐定对儿童口吃的影响。
他们采用双盲交叉研究，给25名6至13岁的口吃儿童服用安慰剂或每天4微克/千克体重的可乐定。通过统计四种基本言语困难的发生次数，以及让家长和教师对口吃的总体程度及其对口吃给孩子带来困扰程度的印象来衡量口吃情况。
可乐定并未改善口吃。
不建议将可乐定作为治疗口吃儿童的有效药物。
