Watine O, Morel P, Bauters F, Ribet M
Clinique Chirurgicale, Hôpital Calmette, CHRU, Lille.
Ann Chir. 1995;49(3):225-31.
Twenty-one patients were admitted to the surgical unit for management of an intra-thoracic mass following treatment of Hodgkin's disease (HD). They consisted of 14 males and 7 females, with a mean age of 34 years (range: 17-62). Seven had recurrent HD, 14 had a non-Hodgkin solid tumour. HD recurrences were treated with repeated chemotherapy with 4 prolonged survivals including 1 relapse (40 to 84 months follow-up). Non-Hodgkin tumours were 13 lung carcinomas, which were resected in 4 cases, with only 1 prolonged survival (54 months) and malignant schwannoma. HD recurrences are observed equally in both young males and females and are subsequent to a mediastinal location of the disease, after an average 3.2 years. They are located on the borders or irradiation fields. Repeated chemotherapy is effective. Carcinomas more often appear in males, at an older age, in a favorable clinical context, after an average 10.2 years. Their prognosis is very poor. Irradiation and chemotherapy contribute to their development. Long-term risks of HD treatment must be considered.
21例患者在接受霍奇金病（HD）治疗后因胸腔内肿块入住外科病房。其中男性14例，女性7例，平均年龄34岁（范围：17 - 62岁）。7例为复发性HD，14例为非霍奇金实体瘤。复发性HD采用重复化疗，4例长期存活，包括1例复发（随访40至84个月）。非霍奇金肿瘤包括13例肺癌，4例接受了手术切除，仅1例长期存活（54个月）以及恶性神经鞘瘤。HD复发在年轻男性和女性中均有观察到，且在疾病纵隔定位后平均3.2年出现。它们位于边界或照射野。重复化疗有效。肺癌更常出现在男性中，年龄较大，处于良好的临床背景下，平均在10.2年后出现。其预后非常差。放疗和化疗促使其发生。必须考虑HD治疗的长期风险。
