O'Morchoe P J, Riad W, Cowles L T, Dorsch R F, Frost J K
Acta Cytol. 1976 Mar-Apr;20(2):132-6.
Significant changes in the urinary cellular pattern can be attributed to renal allograft radiation, as distinct from those associated with immunologic rejection of the transplated kidney. These changes consist of nuclear multiplicity, wrinkling of the nuclear membrane, a "coffee bean" appearance of the nucleus, and increase in nuclear size, areas of decreased density and vacuolation of the cytoplasm, and perinuclear halos. The severity of the changes was categorized as "mild", "moderate", or "marked", according to the number of the above changes which were present, and was more evident in cells of transitional epithelial origin than of tubular origin. Some correlation was found between the severity of the cellular radiation changes and the survival time of the kidney.
尿细胞形态的显著变化可归因于肾移植受者接受的放疗，这与移植肾免疫排斥反应相关的变化不同。这些变化包括核多形性、核膜皱缩、核呈“咖啡豆”样外观、核增大、细胞质密度降低区域及空泡形成，以及核周晕。根据出现上述变化的数量，将变化的严重程度分为“轻度”、“中度”或“显著”，且这些变化在移行上皮来源的细胞中比肾小管来源的细胞中更明显。细胞放疗变化的严重程度与肾脏存活时间之间存在一定相关性。
