Benignus V A
Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27111, USA.
Aviat Space Environ Med. 1995 Apr;66(4):369-74.
A computer-based physiological model of respiratory gas exchange, which considered variation in inhaled oxygen and carbon dioxide, was modified to include the effects of inhaled carbon monoxide. Output from the modified model consists of 60 variables, including blood, alveolar and tissue gases, ventilatory function and carboxyhemoglobin. Extensive testing demonstrated that this model produced accurate results for known problems and physiologically plausible results for situations in which the results were not empirically known. Estimates of the effects of simultaneous continuously varying exposure to carbon monoxide, oxygen and carbon dioxide cannot be practically obtained with other extant methods. The modified model receives input from two computer files containing environmental and subject physiological variables. These files allow a continuous dynamic multi-gas exposure simulation or actual exposure data profiles. Up to four outputs can be selected for plotting or stored in a file for later analysis.
一个基于计算机的呼吸气体交换生理模型，该模型考虑了吸入氧气和二氧化碳的变化，经过修改后纳入了吸入一氧化碳的影响。修改后模型的输出包括60个变量，如血液、肺泡和组织气体、通气功能以及碳氧血红蛋白。大量测试表明，该模型对于已知问题能得出准确结果，对于尚无经验数据的情况也能得出生理上合理的结果。其他现有方法实际上无法获得一氧化碳、氧气和二氧化碳同时持续变化暴露影响的估计值。修改后的模型从两个包含环境和受试者生理变量的计算机文件接收输入。这些文件允许进行连续动态多气体暴露模拟或实际暴露数据概况分析。最多可选择四个输出进行绘图或存储在文件中以供后续分析。
