Bryans M, Lucas J M, Knobloch T J, Wilkie N M, Lang J C
Department of Hematology and Oncology, Ohio State University, Columbus 43210, USA.
Biochem Biophys Res Commun. 1995 Jun 15;211(2):519-27. doi: 10.1006/bbrc.1995.1844.
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has minimal effect on activity of the FGF-4 promoter alone.
FGF-4基因表达的调控既受启动子中的元件控制，也受位于第三外显子非翻译区的增强子结构域控制。我们已经确定转录因子NF-Y与FGF-4启动子结合。我们通过突变分析进一步表明，NF-Y的结合对于FGF-4增强子活性至关重要，但对单独的FGF-4启动子活性影响最小。
