Ghosh P K, Mukherjea M
Department of Biochemistry, University College of Science, Calcutta, India.
Biochim Biophys Acta. 1995 Jun 14;1236(2):317-22. doi: 10.1016/0005-2736(95)00066-c.
The syncytiotrophoblastic brush-border membrane (BBM) of human placenta plays a vital role in the exchange of metabolites between mother and developing fetus. The fluidity of this membrane renders its selective permeable character. To meet the changing needs of the growing fetus with the progress of gestational age changes in the composition and properties of BBM occur. In the present study, decrease in cholesterol/phospholipid ratio of BBM indicated an increase in fluidity with advancement of gestational age. Measurement of the steady state fluorescence anisotropy of labeled liposomes prepared from lipid extract of BBM as well as that of labeled BBM vesicles prepared from native BBM shows decrease in restriction of the bound dye molecule with increased gestational age. Decrease in transition temperature of BBM and enhanced glucose transport through it have been observed with advancement of pregnancy.
人胎盘的合体滋养层刷状缘膜（BBM）在母体与发育中的胎儿之间的代谢物交换中起着至关重要的作用。该膜的流动性赋予其选择性渗透特性。随着胎龄的增加，为满足不断生长的胎儿不断变化的需求，BBM的组成和性质会发生变化。在本研究中，BBM的胆固醇/磷脂比值降低表明随着胎龄的增加流动性增加。用BBM脂质提取物制备的标记脂质体以及用天然BBM制备的标记BBM囊泡的稳态荧光各向异性测量显示，随着胎龄增加，结合染料分子的受限程度降低。随着妊娠进展，观察到BBM的转变温度降低，且通过它的葡萄糖转运增强。
