Kaul H L, Jayalaxmi T, Gode G R, Mitra D K
Anaesthesia. 1976 Jun;31(5):698-701. doi: 10.1111/j.1365-2044.1976.tb11853.x.
Intracranial pressure changes were observed in 10 children with hydrocephalus after ketamine administration. Three patients showed an elevation of pressure and a fall was observed in 7 patients. Two more patients who were given ketamine while under general anaesthesia and IPPV also showed a fall in pressure. No explanation is forthcoming at present for such an unusual response, but an altered cerebral vascular response in the presence of promethazine and general anaesthesia has been postulated.
对10例脑积水患儿在给予氯胺酮后观察颅内压变化。3例患者颅内压升高，7例患者颅内压下降。另外2例在全身麻醉和间歇正压通气下给予氯胺酮的患者也出现颅内压下降。目前对于这种异常反应尚无解释，但推测在有异丙嗪和全身麻醉的情况下脑血管反应发生了改变。
