Givens T G, Murray M M, Baker R C
Department of Pediatrics, University of Cincinnati School of Medicine, Ohio, USA.
Arch Pediatr Adolesc Med. 1995 Jul;149(7):808-11. doi: 10.1001/archpedi.1995.02170200098016.
To determine whether an over-the-counter shampoo containing 1% selenium sulfide would have sporicidal activity equal to that of a 2.5% selenium sulfide prescription lotion in the adjunctive treatment of tinea capitis infection.
Prospective randomized nonblinded clinical trial.
Outpatient clinics and emergency department of a children's hospital.
Fifty-four patients between the ages of 1 and 15 years with culture-proved tinea capitis infection caused by Trichophyton tonsurans enrolled during a 14-month period.
Patients were randomized to receive 2.5% selenium sulfide lotion, 1% selenium sulfide shampoo, or a bland, nonmedicated shampoo with which they were instructed to shampoo twice weekly. All received 15 mg/kg per day of griseofulvin. Dermatophyte cultures of the affected area of each patient's scalp were obtained on enrollment and every 2 weeks until a negative culture was obtained from a previously infected area.
Survival data analysis demonstrated that both the 2.5% selenium sulfide and 1% selenium sulfide preparations were superior to the nonmedicated control shampoo in terms of the time required to eliminate shedding of viable spores. When compared with each other, there was no difference between the 2.5% selenium sulfide and 1% selenium sulfide preparations in time required to produce a negative culture.
Commercially available 1% selenium sulfide shampoo is an equally effective yet less expensive alternative sporicidal therapy in the adjunctive treatment of tinea capitis infection.
确定一种含1%硫化硒的非处方洗发水在头癣感染辅助治疗中是否具有与2.5%硫化硒处方洗剂相同的杀孢子活性。
前瞻性随机非盲临床试验。
一家儿童医院的门诊和急诊科。
在14个月期间招募的54名年龄在1至15岁之间、经培养证实由断发毛癣菌引起头癣感染的患者。
患者被随机分为接受2.5%硫化硒洗剂、1%硫化硒洗发水或一种温和的、不含药物的洗发水，并被指示每周用其洗头两次。所有患者均接受每日15mg/kg的灰黄霉素治疗。在入组时以及每2周采集每位患者头皮感染部位的皮肤癣菌培养物，直至先前感染部位获得阴性培养结果。
生存数据分析表明，就消除活孢子脱落所需时间而言，2.5%硫化硒制剂和1%硫化硒制剂均优于不含药物的对照洗发水。相互比较时，2.5%硫化硒制剂和1%硫化硒制剂在获得阴性培养结果所需时间上没有差异。
市售的1%硫化硒洗发水在头癣感染的辅助治疗中是一种同样有效但成本更低的杀孢子替代疗法。
