Pesonen T, Holmalahti J, Pohjola J
Military Pharmacy, Helsinki, Finland.
J Chromatogr B Biomed Appl. 1995 Mar 10;665(1):222-5. doi: 10.1016/0378-4347(94)00514-6.
A reversed-phase high-performance liquid chromatographic method for the determination of chlorhexidine in saliva is reported. The method developed includes a simple and short sample preparation with a one-step extraction procedure and a short total chromatographic run time of 5 min. In a preliminary pharmacokinetic study with a healthy volunteer the chlorhexidine concentration found in saliva after 12 h was 0.8 microgram/ml.
报道了一种反相高效液相色谱法测定唾液中的洗必泰。所开发的方法包括简单且简短的样品制备，采用一步萃取程序，总色谱运行时间短，仅5分钟。在一项针对健康志愿者的初步药代动力学研究中，12小时后唾液中洗必泰的浓度为0.8微克/毫升。
