Plusquellec Y, Houin G
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
Med Eng Phys. 1995 Apr;17(3):172-6. doi: 10.1016/1350-4533(95)95706-g.
A pharmacokinetic model is used to take into account multiple recirculations of drug occurring at various times after gall bladder emptying. If a dose D is initially administed, due to recirculation, an effective amount A* reaches the body. This value A* is expressed as a function of D and the model parameters, after oral administration or intravenous injection. Using areas under curves in two different situations, the reabsorption rate may be identified.
