Shimura T, Hagihara M, Takebe K, Munkhbat B, Tsuji K
Department of Transplantation Immunology, School of Medicine, Tokai University, Kanagawa-Ken, Japan.
Cell Transplant. 1995;4 Suppl 1:S45-7. doi: 10.1016/0963-6897(94)00064-q.
The survival of allogeneic fetal liver fragments in the omentum was analyzed in rats. The lymphocyte subsets of the spleen and peripheral blood were also examined. When the fetal liver fragments were transplanted into the omentum, they survived for 2 wk, whereas adult liver fragments survived only 1 wk. In fetal liver fragments transplantation, the CD8 positive lymphocyte percentage in peripheral blood decreased significantly 3 wk after transplantation in comparison with that in adult liver fragment transplantation. The skin graft of the donor party showed a longer median survival time in rats receiving fetal liver fragment transplants than that in recipients of adult liver fragments. Although further study is needed, allogeneic fetal liver fragments survived longer in the omentum than reported elsewhere, and the decrease of CD8 positive peripheral blood lymphocytes may have been the reason for this.
在大鼠中分析了同种异体胎儿肝脏碎片在大网膜中的存活情况。同时也检测了脾脏和外周血的淋巴细胞亚群。当将胎儿肝脏碎片移植到大网膜中时，它们存活了2周，而成人肝脏碎片仅存活1周。在胎儿肝脏碎片移植中，与成人肝脏碎片移植相比，外周血中CD8阳性淋巴细胞百分比在移植后3周显著降低。供体方的皮肤移植在接受胎儿肝脏碎片移植的大鼠中的中位存活时间比接受成人肝脏碎片移植的大鼠更长。尽管需要进一步研究，但同种异体胎儿肝脏碎片在大网膜中的存活时间比其他地方报道的更长，外周血CD8阳性淋巴细胞的减少可能是其原因。
