Wauquier A, Niemegeers C J
Psychopharmacologia. 1976 Mar 16;46(2):179-83. doi: 10.1007/BF00421389.
The effects of different subcutaneous doses of fentanyl (0.02, 0.04, 0.08, and 0.16 mg/kg), piritramide (0.63, 2.50, 10.0 and 40.0 mg/kg), and morphine (2.50, 5.00, 10.0 and 20.0 mg/kg) on self-stimulation in rats were studied. Different stimulus parameter combinations (SPC) inducing low, high or intermediate control response rates (CRR) were applied during the same experimental sessions. The three narcotic analgesics induced response depression (RD) and response stimulation (RS). RS was mostly observed at low dose levels; RD was dose-related. SPC's inducing low CRR were more sensitive than those inducing high CRR. Fentanyl was more potent than piritramide and than morphine. The RD is related to motor incapacitation, as the doses needed to effectively reduce self-stimulation also induced obvious catatonia. The RS probably is a more specific effect reflecting sensitization of structures involved in reinforcement of behavior.
研究了不同皮下剂量的芬太尼（0.02、0.04、0.08和0.16毫克/千克）、匹利卡明（0.63、2.50、10.0和40.0毫克/千克）以及吗啡（2.50、5.00、10.0和20.0毫克/千克）对大鼠自我刺激行为的影响。在同一实验过程中，应用了诱导低、高或中等控制反应率（CRR）的不同刺激参数组合（SPC）。这三种麻醉性镇痛药均引起反应抑制（RD）和反应兴奋（RS）。RS大多在低剂量水平观察到；RD与剂量相关。诱导低CRR的SPC比诱导高CRR的SPC更敏感。芬太尼比匹利卡明和吗啡更有效。RD与运动失能有关，因为有效降低自我刺激所需的剂量也会诱发明显的紧张症。RS可能是一种更具特异性的效应，反映了参与行为强化的结构的敏化。
