Huhman K L, Babagbemi T O, Albers H E
Department of Biology, Georgia State University, Atlanta 30302-4010, USA.
Brain Res. 1995 Mar 27;675(1-2):333-6. doi: 10.1016/0006-8993(95)00018-l.
Microinjection of neuropeptide Y (NPY) into the suprachiasmatic nucleus of the hypothalamus (SCN) during the middle of the subjective day (i.e. circadian time 6) causes large phase advances in circadian rhythms. The present study demonstrates that microinjection of the gamma-aminobutyric acid (GABA) antagonist, bicuculline, completely blocks NPY-induced phase advances. These data indicate that GABAA activity within the SCN may mediate the phase shifting effects of some stimuli on the circadian pacemaker.
在主观日的中期（即昼夜节律时间6），向下丘脑视交叉上核（SCN）微量注射神经肽Y（NPY）会导致昼夜节律大幅提前。本研究表明，微量注射γ-氨基丁酸（GABA）拮抗剂荷包牡丹碱可完全阻断NPY诱导的相位提前。这些数据表明，SCN内的GABAA活性可能介导某些刺激对昼夜节律起搏器的相位移动效应。
