Kibwage I O, Machine A, Hagos B, Hoogmartens J
Department of Pharmacy, College of Health Sciences, University of Nairobi.
East Afr Med J. 1995 Mar;72(3):194-7.
Seventeen brands of antacid products available on the Kenya market were investigated for their acid neutralising capacity and sodium content. Thirteen tablet products gave neutralising capacity per tablet of between 4.7 to 14.12 mMol hydrochloric acid. The neutralising capacities for the suspensions ranged between 11.97 to 34.32 mMol hydrochloric acid for 10ml suspension. The lowest neutralising capacities were obtained for products based on compound magnesium trisilicate and higher capacities for those containing magaldrate, or magnesium hydroxide or magnesium carbonate in combination with other ingredients. The fastest rate of neutralization was obtained with preparations containing carbonates and the lowest by compound magnesium trisilicate. The sodium content for the preparations was between < 0.001 mEq to 0.732 mEq sodium per minimum recommended dose. The study shows a high degree of variation in both the acid neutralising capacities and the sodium content of the different brands investigated.
对肯尼亚市场上现有的17种抗酸产品品牌进行了酸中和能力和钠含量调查。13种片剂产品每片的中和能力为4.7至14.12毫摩尔盐酸。10毫升悬浮液的中和能力在11.97至34.32毫摩尔盐酸之间。基于复方三硅酸镁的产品中和能力最低，而含有铝镁加、氢氧化镁或碳酸镁与其他成分组合的产品中和能力较高。含碳酸盐的制剂中和速度最快，复方三硅酸镁的中和速度最慢。制剂的钠含量按最低推荐剂量计算，每剂含钠量在<0.001毫当量至0.732毫当量之间。该研究表明，所调查的不同品牌产品在酸中和能力和钠含量方面都存在很大差异。
