Koenig W
Department of Internal Medicine II (Cardiology), University of Ulm Medical Centre, Germany.
Eur Heart J. 1995 Mar;16 Suppl A:54-9. doi: 10.1093/eurheartj/16.suppl_a.54.
This article provides an overview of recently accumulated evidence on the pathogenetic role of fibrinogen in various vascular beds; and tries to elucidate determinants for patients' susceptibility so that subgroups at particular risk of severe clinical complications can be characterized more accurately. Based on the considerably elevated risk of cardiovascular complications associated with increased levels of plasma fibrinogen, the potential value of lowering fibrinogen in the primary or secondary prevention of atherosclerotic disease is now recognized as an important topic for consideration. Recent progress in this field will also be reviewed.
本文概述了近期积累的关于纤维蛋白原在各种血管床中的致病作用的证据；并试图阐明患者易感性的决定因素，以便更准确地界定具有严重临床并发症特殊风险的亚组。鉴于血浆纤维蛋白原水平升高与心血管并发症风险显著增加相关，降低纤维蛋白原在动脉粥样硬化疾病一级或二级预防中的潜在价值现在被认为是一个重要的考虑主题。该领域的最新进展也将得到综述。
