Singh K, Nain C K, Singh V, Ganguly N K
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Indian J Gastroenterol. 1995 Apr;14(2):48-50.
Sucralfate is known to protect gastroduodenal mucosa and thereby facilitate healing of peptic ulcer. The mechanism of action of this drug is still not fully known.
We studied the effect of sucralfate treatment on gastric bicarbonate secretion in 16 patients with duodenal ulcer.
Sucralfate administration (3 g daily for 4 weeks) stimulated bicarbonate secretion from 3.1 +/- 1.2 mmol/h to 4.6 +/- 2.0 mmol/h (p < 0.05). Gastric juice volume as well as non-parietal volume secretion also increased significantly after sucralfate therapy (p < 0.05).
Sucralfate causes stimulation of non-parietal volume-dependent gastric bicarbonate secretion.
已知硫糖铝可保护胃十二指肠黏膜，从而促进消化性溃疡的愈合。该药物的作用机制仍不完全清楚。
我们研究了硫糖铝治疗对16例十二指肠溃疡患者胃碳酸氢盐分泌的影响。
给予硫糖铝（每日3克，共4周）后，碳酸氢盐分泌从3.1±1.2毫摩尔/小时增加至4.6±2.0毫摩尔/小时（p<0.05）。硫糖铝治疗后胃液量以及非壁细胞容量分泌也显著增加（p<0.05）。
硫糖铝可刺激非壁细胞容量依赖性胃碳酸氢盐分泌。
