Inhibition of phosphatidylinositol-specific phospholipase C activity by fluvirucin B2.
作者信息
Ui H, Imoto M, Umezawa K
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama.
出版信息
J Antibiot (Tokyo). 1995 May;48(5):387-90. doi: 10.7164/antibiotics.48.387.
PMID:7797440
Abstract
We isolated fluvirucin B2 from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC50 of 1.6 micrograms/ml. Fluvirucin B2 also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.
摘要
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